platelet refractoriness definition
A mini-review on platelet refractoriness
tion of platelet concentrates from random donors as indicated by the lack of an ade-quate post-transfusion platelet count increment. This condition goes under the term of platelet refractoriness.1 Although a certain level of theoretical consensus on the definition and management of platelet refractoriness existsas witnessed by a
EDUCATIONAL COMMENTARYPLATELET
· Platelets are a critical component for maintaining hemostasis in patients who are actively bleeding and those with low number of platelets or with non-functional platelets. When a blood vessel is injured platelets adhere to the exposed collagen forming the primary platelet plug. Platelets then aggregate at the injured site secreting various substances that promote vasoconstriction clot
Platelet RefractorinesstouchONCOLOGY
· The definition of refractoriness to platelet transfusions Transfusion Med 19922 35–41. Rebulla P Formulae for the detection of platelet refractoriness Transfusion Med 19933 91–3. Doughty HA Murphy MF Metcalfe P et al. Relative importance of immune and non-immune causes of platelet refractoriness Vox Sang 199466 200–205.
Assessing Platelet Refractoriness and the Appropriate Use
· A formal and specific definition for platelet refractoriness using the CCI was outlined in the Trial to Reduce Alloimmunization to Platelets (TRAP) study. 4 5. Platelet Refractoriness = A poor response to platelet transfusions on at least two separate sequential occasions using ABO identical platelet units that are less than 72 hours old with
Platelet transfusion refractoriness definition of
Thrombocytopenia is closely related to bleeding episodes in patients following HSCT.2 3 If platelet refractoriness is associated with GI bleeding routine hemostatic interventions may not help.11 Most patients in our case series remained dependent on platelet transfusion five patients became platelet transfusion refractoriness which would contribute to the failure of the hemostatic therapy.
Platelet Refractoriness
· Platelet Refractoriness Paolo Rebulla is Director of the Centre of Transfusion Medicine Cellular Therapy and Cryobiology at the Ospedale Maggiore Policlinico Mangiagalli Regina Elena Foundation Milan. He was Chairman of the Biomedical Excellence for Safer
Pathology OutlinesPlatelet refractoriness
· Definition / general. Platelet refractoriness is the inability to get an adequate increase in platelet count after transfusion ( Arch Pathol Lab Med 409 Haematologica 200590 247 ) Immune causes antiplatelet or anti-HLA antibodies after multiple exposures from transfusion pregnancy or transplantation ( Transfusion 200545 761
Platelet transfusion refractorinessHod2008British
· Definition of platelet refractoriness. Platelet refractoriness can be simply defined as a post-transfusion platelet increment that is less than expected. The difficulty in making this diagnosis arises in the specifics with a lack of agreement regarding the precise definition (Phekoo et al 1997).
Cited by 295
Refractoriness definition of refractoriness by Medical
Absolute platelet refractoriness associated with HLA antibodies A case report It can be seen that processing of refractory gold ores can yield low rates so they require implementation of extra stages such as roasting in order to eliminate the compounds that cause the refractoriness (e.g.
Platelet RefractorinesstouchONCOLOGY
· The definition of refractoriness to platelet transfusions Transfusion Med 19922 35–41. Rebulla P Formulae for the detection of platelet refractoriness Transfusion Med 19933 91–3. Doughty HA Murphy MF Metcalfe P et al. Relative importance of immune and non-immune causes of platelet refractoriness Vox Sang 199466 200–205.
Platelet Refractoriness
· Platelet Refractoriness Paolo Rebulla is Director of the Centre of Transfusion Medicine Cellular Therapy and Cryobiology at the Ospedale Maggiore Policlinico Mangiagalli Regina Elena Foundation Milan. He was Chairman of the Biomedical Excellence for Safer
Platelet Refractoriness
· Platelet Refractoriness Paolo Rebulla is Director of the Centre of Transfusion Medicine Cellular Therapy and Cryobiology at the Ospedale Maggiore Policlinico Mangiagalli Regina Elena Foundation Milan. He was Chairman of the Biomedical Excellence for Safer
Formulae for the definition of refractoriness to platelet
· Formulae for the definition of refractoriness to platelet transfusion Formulae for the definition of refractoriness to platelet transfusion Rebulla P. 00 00 00 SIR Bishop et al. (1992) reported the results of an elegant study aimed at examining the agreement between different formulae currently used to determine the â success or failureâ of platelet transfusion and in turn to
Formulae for the definition of refractoriness to platelet
· Formulae for the definition of refractoriness to platelet transfusion Formulae for the definition of refractoriness to platelet transfusion Rebulla P. 00 00 00 SIR Bishop et al. (1992) reported the results of an elegant study aimed at examining the agreement between different formulae currently used to determine the â success or failureâ of platelet transfusion and in turn to
The definition of refractoriness to platelet transfusions
· Definition of platelet refractoriness Post-transfusion parameters The post-transfusion platelet count was recorded 1 h after transfusion and again approximately 20 h after transfusion and the following additional parameters were calculated. The platelet increment (PI) was defined as PI=Pz-P where P I is the pre-transfusion platelet count and
Pathology OutlinesPlatelet antibodies
· Definition / general. Either autoimmune (idiopathic thrombocytopenic purpura) alloimmune (neonatal alloimmune thrombocytopenia post-transfusion purpura platelet transfusion refractoriness) or heparin-induced These tests must be ordered and interpreted cautiously considering the clinical presentation (Blood 199789 1112)
Refractoriness definition of refractoriness by Medical
Absolute platelet refractoriness associated with HLA antibodies A case report It can be seen that processing of refractory gold ores can yield low rates so they require implementation of extra stages such as roasting in order to eliminate the compounds that cause the refractoriness (e.g.
The definition of refractoriness to platelet transfusions
The percentage agreement between common definitions of refractoriness was calculated based on these parameters. As the maintenance of platelet counts above 20 x 10(9)/l is a relevant clinical goal for platelet support the values of the CI PI and REC which best corresponded to 1- and 20-h post-transfusion counts of 20 x 10(9)/l were identified.
Cited by 78
Platelet transfusion Alloimmunization and refractoriness
· Platelet refractoriness remains a clinical challenge and it is associated with worse clinical outcomes It is generally under recognised by clinicians with some studies suggesting that from 27 up to 44 of patients have unsatisfactory responses to platelet transfusions Although there are some mathematical formulas that clinicians can use 62 63 a diagnosis of refractoriness can most
HLA-Mediated Platelet Refractoriness American Journal of
· Platelet refractoriness can be attributed to nonimmune or immune causes. Notably nonimmune causes comprise the largest proportion. Immune-mediated platelet refractoriness is indicated by a 1-hour CCI of less than 5 10 9 /L on two sequential occasions. 6 HLA antibody testing and/or HLA typing can then be initiated.
Platelet Refractoriness AACC
However when a patient repeatedly does not respond adequately to their platelet transfusions they are defined as being refractory to platelets and in these cases an
HLA-Mediated Platelet Refractoriness American Journal of
· Platelet refractoriness can be attributed to nonimmune or immune causes. Notably nonimmune causes comprise the largest proportion. Immune-mediated platelet refractoriness is indicated by a 1-hour CCI of less than 5 10 9 /L on two sequential occasions. 6 HLA antibody testing and/or HLA typing can then be initiated.
The definition of refractoriness to platelet transfusions
· Definition of platelet refractoriness Post-transfusion parameters The post-transfusion platelet count was recorded 1 h after transfusion and again approximately 20 h after transfusion and the following additional parameters were calculated. The platelet increment (PI) was defined as PI=Pz-P where P I is the pre-transfusion platelet count and
Platelet transfusion refractoriness how do I diagnose and
· Platelet refractoriness is defined as a repeated suboptimal response to platelet transfusions with lower-than-expected posttransfusion count increments.
Cited by 1A mini-review on platelet refractoriness
tion of platelet concentrates from random donors as indicated by the lack of an ade-quate post-transfusion platelet count increment. This condition goes under the term of platelet refractoriness.1 Although a certain level of theoretical consensus on the definition and management of platelet refractoriness existsas witnessed by a
Platelet Transfusion Alloimmunization and Management of
· Platelet Refractoriness. Platelet refractoriness is a major complication in the management of hypoproliferative thrombocytopenic patients. Platelet refractoriness may be due to immune or non-immune causes. The causes of non-immune refractoriness include fever infection drugs splenomegaly and disseminated intravascular coagulation.
Platelet transfusion refractoriness how do I diagnose and
Platelet refractoriness continues to be a problem for thrombocytopenic patients because the risk of a major spontaneous or life-threatening bleed significantly increases when platelet counts drop below 10 109/L. The majority of patients have nonimmune causes driving the refractoriness such as bleeding medications or diffuse intravascular coagulation however this article is dedicated to
recognition and management of platelet‑refractory
· A critical unmet need is the development of a definition of an adequate response to platelet transfusion which would facilitate early recognition of platelet refractoriness in patients with PFDs who exhibit a normal platelet count. Keywords platelet function disorder Glanzmann s thrombasthenia alloantibodies antiplatelet
Platelet Refractoriness in HemOnc PatientsA
· Platelet Refractoriness. Platelet refractoriness is defined as two consecutive platelet transfusions with 24-hr corrected count increments below 5x10 9 /L. Up to 35 of hematology-oncology patients who depend on platelet transfusion support become refractory to platelets during their treatment. One possible cause of platelet refractoriness is
Refractoriness Article about Refractoriness by The Free
Refractoriness. a short-term decrease in the excitability of nervous or muscle tissue occurring immediately after the manifestation of action potential. It can be detected by the stimulation of nerves and muscles by paired electrical impulses. If the force of the first impulse is sufficient to produce action potential the response to the
Platelet RefractorinesstouchONCOLOGY
· The definition of refractoriness to platelet transfusions Transfusion Med 19922 35–41. Rebulla P Formulae for the detection of platelet refractoriness Transfusion Med 19933 91–3. Doughty HA Murphy MF Metcalfe P et al. Relative importance of immune and non-immune causes of platelet refractoriness Vox Sang 199466 200–205.
American Red Cross HLA Laboratories Playing with Matches
· Platelet Refractoriness A widely accepted definition of refractoriness is when two consecutive platelet transfusions lead to 1 hour post transfusion corrected count increments (CCI) of less than 5000 platelets x m2 per µL. We recommend ABO identical.
Platelet RefractorinesstouchONCOLOGY
· The definition of refractoriness to platelet transfusions Transfusion Med 19922 35–41. Rebulla P Formulae for the detection of platelet refractoriness Transfusion Med 19933 91–3. Doughty HA Murphy MF Metcalfe P et al. Relative importance of immune and non-immune causes of platelet refractoriness Vox Sang 199466 200–205.
